High Shear Online Mixer
INTERTECH has substantial experience in designing, fabrication, erection & commissioning of Large Volume Parental Mixing Solution System based on Online High Shear mixing Technologies. In this design, no internal agitators are fitted which leads to no cross contamination & deviation in cleaning validation. Entire vessel from inside is electro polished leaving no space of crevices & ridges henceforth no place for any bioorganic to exist. This design is economical in investment & have far better flexibility in batch size variation as High Shear Homogenizer / Emulsifier is externally fitted in re-circulation. Online temp. mapping of re-circulatory pipe line & all points well within tanks are there for cleaning validation. Head of external homogenizer is quick release type & compatible to sterilization. Agitator seals are capable of sustaining Pure steam pressure for SIP cycle.
Better & faster dissolution of solute into main WFI stream is achieved in this design as mixing is done at higher RPM & re-circulation of mixed liquid is at tangential position in tank. Therefore vortex created also enhances mixi
Construction Details
- Inside the Online Homogenizer, there is provision of 2 stage to 4 stage disintegrating head which are capable of dissolving any solute by high shear impact made of 316L stainless steel housing.
- Entire Mixing Tank is design of internal pressure for SIP cycle & for Vacuum application also.
- A drive unit mounts externally to the vessel and can be quickly and easily removed using a TC type connection. This is particularly useful when sterilizing the vessel & autoclave for Homogenizer parts.
- The vessel can be cleaned in place (CIP) using spray balls and/or by immersion in a cleaning fluid. For maximum effect rotating type spray heads are recommended. Sterilization in place (SIP) is possible with temperatures up to 145°C.
- A wide range of operating controls are supplied from a simple stand-alone panel to a fully integrated automation system.
- The Ultra Clean Mixer has been designed to meet the critical standards of the Pharmaceutical and Biotech industries
- These Mixer complies with current Good Manufacturing Practices and the requirements of Indian, British and the United States Pharmacopoeia of Water for Injection. All documents related to Factory Acceptance Test (FAT) like Installation Qualification (IQ), Operation Qualification (OQ) and Performance Qualification (PQ) are provided as a part of the operating manual.
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